Exploration of immune systems in prokaryotes, such as restriction‐modification or CRISPR‐Cas, shows that both innate and adaptive systems possess programmed cell death (PCD) potential. The key outstanding question is how the immune systems sense and “predict” infection outcomes to “decide” whether to fight the pathogen or induce PCD. There is a striking parallel between this life‐or‐death decision faced by the cell and the decision by temperate viruses to protect or kill their hosts, epitomized by the lysis‐lysogeny switch of bacteriophage Lambda. (...) Immune systems and temperate phages sense the same molecular inputs, primarily, DNA damage, that determine whether the cell lives or dies. Because temperate (pro)phages are themselves components of prokaryotic genomes, their shared “interests” with the hosts result in coregulation of the lysis‐lysogeny switch and immune systems that jointly provide the cell with the decision machinery to probe and predict infection outcomes, answering the life‐or‐death question. (shrink)

This paper presents new constructions of models of Hume's Principle and Basic Law V with restricted amounts of comprehension. The techniques used in these constructions are drawn from hyperarithmetic theory and the model theory of fields, and formalizing these techniques within various subsystems of second-order Peano arithmetic allows one to put upper and lower bounds on the interpretability strength of these theories and hence to compare these theories to the canonical subsystems of second-order arithmetic. The main results of this paper (...) are: (i) there is a consistent extension of the hyperarithmetic fragment of Basic Law V which interprets the hyperarithmetic fragment of second-order Peano arithmetic, and (ii) the hyperarithmetic fragment of Hume's Principle does not interpret the hyperarithmetic fragment of second-order Peano arithmetic, so that in this specific sense there is no predicative version of Frege's Theorem. (shrink)

Rudolf Carnap is well known for his attack on metaphysics, and W. V. Quine is equally well known for his attack on Carnap’s analytic/synthetic distinction. Receiving far less attention is their basic agreement that a properly scientific approach to philosophy should eliminate the metaphysical excesses of the past. This paper aims to remedy this. It focuses initially on the development of Carnap’s rejection of metaphysics from 1932 to 1950 and the role that analyticity plays. It then turns to Quine, emphasizing (...) his basic agreement with Carnap over the elimination of metaphysics and what this looks like without the analytic/synthetic distinction. (shrink)

Frege's theorem says that second-order Peano arithmetic is interpretable in Hume's Principle and full impredicative comprehension. Hume's Principle is one example of an abstraction principle, while another paradigmatic example is Basic Law V from Frege's Grundgesetze. In this paper we study the strength of abstraction principles in the presence of predicative restrictions on the comprehension schema, and in particular we study a predicative Fregean theory which contains all the abstraction principles whose underlying equivalence relations can be proven to be equivalence (...) relations in a weak background second-order logic. We show that this predicative Fregean theory interprets second-order Peano arithmetic. (shrink)

On March 30, 1995, the Supreme Court of Nevada, in Greco v. United States, determined that medical professionals who fail to make a timely diagnosis of gross and disabling fetal defects, thereby denying a pregnant woman her right to terminate a pregnancy, had acted negligently, and a malpractice claim could be brought against them. The court supported the plaintiff's claim of “wrongful birth,” but determined that the disabled child born to the plaintiff has no personal cause of action for “wrongful (...) life.” Sundi Greco, the plaintiff, alleged that her doctors at Nellis Air Force Base in Nevada failed to make a timely diagnosis of her son's physical defects and abnormalities before his birth. Their negligence denied her the opportunity to terminate her pregnancy, causing her damages attendant to the avoidable birth of a child with birth defects. On her child's behalf, Greco asserted that the physicians' negligence, and resultant denial of his mother's right to terminate the pregnancy, allowed him to be born into a “grossly abnormal life of pain and deprivation.”. (shrink)

Rudolf Carnap and W. V. O Quine have long been seen as key figures of analytic philosophy who are opposed to each other, due in no small part to their famed debate over the analytic/synthetic distinction. This volume of new essays assembles for the first time a number of scholars of the history of analytic philosophy who see Carnap and Quine as figures largely sympathetic to each other in their philosophical views. The essays acknowledge the differences which exist, but through (...) their emphasis on Carnap and Quine's shared assumption about how philosophy should be done-that philosophy should be complementary to and continuous with the natural and mathematical sciences-our understanding of how they diverge is also deepened. This volume reshapes our understanding not only of Carnap and Quine, but of the history of analytic philosophy generally. (shrink)

v. 1. Foundations -- v. 2. The mind-body problem -- v. 3. Intentionality -- v. 4. Consciousness.

In Making it Explicit Robert Brandom claims that perspectivally hybrid de re attitude ascriptions explain what an agent actually did, from the point of view of the ascriber, whether or not that was what the agent intended to do. There is a well-known problem, however, first brought to attention by Quine, but curiously ignored by Brandom, that threatens to undermine the role of de re ascriptions in the explanation of action, a problem that stems directly from the fact that, unlike (...) de dicto ascriptions, they permit the attribution of inconsistent attitudes to agents. I propose a solution to the problem which I believe is consistent with Brandom’s approach to the nature of intentionality and the explanation of action. (shrink)

I discuss Philip Pettit’s argument that appreciation is not a proper response to value because it fails to satisfy the non-iteration constraint, according to which, where V is a value and R is a response to value, R-ing V must not be distinct from R-ing R-ing V. After motivating the non-iteration constraint and conceding that appreciation fails to satisfy the constraint, I argue that the consequentialist’s preferred response to value, promotion, also violates the constraint, leaving Pettit with a dilemma: if (...) he insists on the constraint, then promotion is not a proper response to value; if he does not insist on the constraint, then his argument against appreciation as a proper response to value fails. (shrink)

In this paper I attempt to discover the object of Aristotle’s God’s νόησις in Metαphysics Λ.9. In Section I, I catalogue existing interpretations and mention the two key concepts of (i) God’s substancehood and (ii) his metaphysical simplicity. In Section II, I explore the first two aporiae of Λ.9 – namely (1) what God’s οὐσία is and (2) what God intelligizes. In Section III, I show how Aristotle solves these aporiae by contending that God’s οὐσία is actually intelligizing, and being (...) determined to do so by himself, and that the object of his νόησις is himself, such that he intelligizes his own οὐσία, and I explain what this means. In Section IV, I present the second pair of aporiae in Λ.9 and show how, by solving these, Aristotle clarifies the position arrived at in Section III. Lastly, in Section V, I present the final aporia and its solution, and conclude that Aristotle’s God is a radically-unified Narcissus-God who intelligizes his own οὐσία. (shrink)

The injective version of Cantor’s theorem appears in full second-order logic as the inconsistency of the abstraction principle, Frege’s Basic Law V (BLV), an inconsistency easily shown using Russell’s paradox. This incompatibility is akin to others—most notably that of a (Dedekind) infinite universe with the Nuisance Principle (NP) discussed by neo-Fregean philosophers of mathematics. This paper uses the Burali–Forti paradox to demonstrate this incompatibility, and another closely related, without appeal to principles related to the axiom of choice—a result hitherto unestablished. (...) It discusses both the general interest of this result, its interest to neo-Fregean philosophy of mathematics, and the potential significance of the Burali–Fortian method of proof. (shrink)

Analizo en este trabajo el alcance real de la idea de "espíritu del pueblo" en el pensamiento jurídico de F. C. v. Savigny. Sugiero la posibilidad de que las apelaciones al espíritu del pueblo no sean más que una pantalla retórica que encubre una opción de fondo por una visión lógico-sistemática (y ahistórica) del Derecho, en la que jugaría un papel importante la idealización del Derecho romano en cuanto ratio scripta.

Analizo en este trabajo el alcance real de la idea de "espíritu del pueblo" en el pensamiento jurídico de E C v Savigny Sugiero la posibilidad de que las apelaciones al espíritu del pueblo no sean más que una pantalla retórica que encubre una opción de fondo por una visión lógico-sistemática (y ahistórica) del Derecho, en la que jugaría un papel importante la idealización del Derecho romano en cuanto ratio scripta.

Some modern cosmological models predict the appearance of Boltzmann Brains: observers who randomly fluctuate out of a thermal bath rather than naturally evolving from a low-entropy Big Bang. A theory in which most observers are of the Boltzmann Brain type is generally thought to be unacceptable, although opinions differ. I argue that such theories are indeed unacceptable: the real problem is with fluctuations into observers who are locally identical to ordinary observers, and their existence cannot be swept under the rug (...) by a choice of probability distributions over observers. The issue is not that the existence of such observers is ruled out by data, but that the theories that predict them are cognitively unstable: they cannot simultaneously be true and justifiably believed. (shrink)

Quine's set theory, New Foundations, has often been treated as an anomaly in the history and philosophy of set theory. In this book, Sean Morris shows that it is in fact well-motivated, emerging in a natural way from the early development of set theory. Morris introduces and explores the notion of set theory as explication: the view that there is no single correct axiomatization of set theory, but rather that the various axiomatizations all serve to explicate the notion of (...) set and are judged largely according to pragmatic criteria. Morris also brings out the important interplay between New Foundations, Quine's philosophy of set theory, and his philosophy more generally. We see that his early technical work in logic foreshadows his later famed naturalism, with his philosophy of set theory playing a crucial role in his primary philosophical project of clarifying our conceptual scheme and specifically its logical and mathematical components. (shrink)

Cosmological models that invoke a multiverse - a collection of unobservable regions of space where conditions are very different from the region around us - are controversial, on the grounds that unobservable phenomena shouldn't play a crucial role in legitimate scientific theories. I argue that the way we evaluate multiverse models is precisely the same as the way we evaluate any other models, on the basis of abduction, Bayesian inference, and empirical success. There is no scientifically respectable way to do (...) cosmology without taking into account different possibilities for what the universe might be like outside our horizon. Multiverse theories are utterly conventionally scientific, even if evaluating them can be difficult in practice. (shrink)

Graduate-level textbook in general relativity.

In this study, we examined students' attitudes toward cheating and whether they would report instances of cheating they witnessed. Data were collected from three educational institutions in Singapore. A total of 518 students participated in the study. Findings suggest that students perceived cheating behaviors involving exam-related situations to be serious, whereas plagiarism was rated as less serious. Cheating in the form of not contributing one's fair share in a group project was also perceived as a serious form of academic misconduct, (...) although a majority of the students admitted having engaged in such behavior. With regard to the prevalence of academic cheating, our findings suggest that students are morally ambivalent about academic cheating and are rather tolerant of dishonesty among their peers. On the issue of whether cheating behaviors should be reported, our findings revealed that a majority of students chose to take the expedient measure of ignoring the problem rather than to blow the whistle on their peers. Implications of our findings are discussed. (shrink)

Many commentators now view Quine's ‘Truth by Convention’ as a flawed criticism of Carnap. Gary Ebbs argued recently that Quine never intended Carnap as his target. Quine's criticisms were part of his attempt to work out his own scientific naturalism. I agree that Carnap was not Quine's target but object that Quine's criticisms were wholly internal to his own philosophy. Instead, I argue that C.I. Lewis held the kind of truth‐by‐convention thesis that Quine rejects. This, however, leaves Carnap out of (...) the picture. I then show how Quine came to see the earlier criticisms as also having force against Carnap. (shrink)

We propose an operator constraint equation for the wavefunction of the Universe that admits genuine evolution. While the corresponding classical theory is equivalent to the canonical decomposition of General Relativity, the quantum theory contains an evolution equation distinct from standard Wheeler–DeWitt cosmology. Furthermore, the local symmetry principle—and corresponding observables—of the theory have a direct interpretation in terms of a conventional gauge theory, where the gauge symmetry group is that of spatial conformal diffeomorphisms (that preserve the spatial volume of the Universe). (...) The global evolution is in terms of an arbitrary parameter that serves only as an unobservable label for successive states of the Universe. Our proposal follows unambiguously from a suggestion of York whereby the independently specifiable initial data in the action principle of General Relativity is given by a conformal geometry and the spatial average of the York time on the spacelike hypersurfaces that bound the variation. Remarkably, such a variational principle uniquely selects the form of the constraints of the theory so that we can establish a precise notion of both symmetry and evolution in quantum gravity. (shrink)

The article discusses the characteristics of virtuous persons in relation to their social role(s). It explores the key features of the neo-Aristotelian account of right action and some problems for this account in the context of a certain social role. The problem can be characterized as a dilemma. When evaluating an action in some role, one view is that the obligations and requirements of roles could be taken as something already given by social or professional role descriptions, such that the (...) virtuous person must respond to these demands in the right way. Alternatively, the virtuous person could evaluate the role itself in terms of what the “good parent, teacher, doctor” and so on should be like. Using two different neo-Aristotelian approaches to the ethics of professional roles as examples I argue that neither strategy is, as it stands, satisfactory. ‘Internalism’ about role demands takes institutionally specified role requirements in a way that is too strongly determinate for a virtue ethical analysis. On the other side, ‘externalism’ is all too indeterminate in bypassing or failing to accommodate the institutionally determined demands of social or professional roles. These shortcomings contour an “institution shaped gap” in virtue ethics such that it needs to attend to the qualities of social institutions as well as the character and actions of individuals. In response I suggest that there is a distinctly Aristotelian way in which the virtue ethicist can address it, by appeal to the distinctive function or “characteristic activity”— ergon—of the institution. (shrink)

This article argues that Hayek employed a neo-Roman concept of liberty. It will show that Hayek’s definition of liberty conforms to that provided by Philip Pettit and Quentin Skinner, respectively...

A strong moral reason for prohibiting doping in sport is to be found in the bad choices that would be faced by clean athletes in a sporting world that tolerated doping. The case against doping is not, however, to be grounded in the concept of coercion. Instead, it is grounded in a general duty of sport to afford fair opportunity to the goods that are distinctively within sport's sphere of control. The moral reason to prohibit doping need not be balanced (...) against any autonomy claim of athletes who would prefer to dope because, upon closer examination, such claims have no force. The moral reason to prohibit doping does, however, need to be balanced against the enforcement costs imposed on all athletes by effective prohibition. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. 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In Difference and Repetition, Deleuze claims that it is in virtue of a relation of expression which holds between intensive processes of individuation and virtual Ideas that the former determines the latter to be actualised in concrete entities. He is, however, less than forthcoming in this book about exactly how we should understand the relation of expression. This article addresses itself to this lacuna. It clarifies five characteristic features of the expressive relation, partly by drawing on Deleuze's discussion of the (...) relation of expression in Expressionism in Philosophy, party by examining familiar examples of expressive relations. It then maps these characteristic features of expression onto Deleuze's discussion of the relation between Ideas and intensity in Difference and Repetition, showing that virtual Ideas are ontologically inseparable from the intensive processes that both constitute and actualise them in the production of actual entities. By way of conclusion, this expressive account of the relation between the virtual, the actual and the intensive will be compared and contrasted with several leading accounts to be found in the secondary literature. (shrink)

The diverse essays in this volume speak to the relevance of phenomenological and psychological questioning regarding perceptions of the human. This designation, human, can be used beyond the mere identification of a species to underwrite exclusion, denigration, dehumanization and demonization, and to set up a pervasive opposition in Othering all deemed inhuman, nonhuman, or posthuman. As alerted to by Merleau-Ponty, one crucial key for a deeper understanding of these issues is consideration of the nature and scope of perception. Perception defines (...) the world of the perceiver, and perceptual capacities are constituted in engagement with the world – there is co-determination. Moreover, the distinct phenomenology of perception in the spectatorial mode in contrast to the reciprocal mode, deepens the intersubjective and ethical dimensions of such investigations. -/- Questions motivating the essays include: Can objectification and an inhuman gaze serve positive ends? If so, under what constraints and conditions? How is an inhuman gaze achieved and at what cost? How might the emerging insights of the role of perception into our interdependencies and essential sociality from various domains challenge not only theoretical frameworks, but also the practices and institutions of science, medicine, psychiatry and justice? What can we learn from atypical social cognition, psychopathology and animal cognition? Could distortions within the gazer’s emotional responsiveness and habituated aspects of social interaction play a role in the emergence of an inhuman gaze? -/- Perception and the Inhuman Gaze will interest scholars and advanced students working in phenomenology, philosophy of mind, psychology, psychiatry, sociology and social cognition. -/- Table of Contents -/- Introduction -/- Part I. The Gaze in Classical Phenomenology: Perspectives on Objectification -/- 1. Defending the Objective Gaze as a Self-transcending Capacity of Human Subjects -/- Dermot Moran -/- 2. Two Orders of Bodily Objectification: The Look and the Touch -/- Sara Heinämaa -/- 3. On Eliminativism’s Transient Gaze -/- Timothy Mooney -/- 4. Not wholly human. Reading Maurice Merleau-Ponty with Jacques Lacan. -/- Dorothée Legrand -/- 5. Disclosure and the Gendered Gaze in Simone de Beauvoir's Ethics -/- Christinia Landry -/- Part II. Vision, Perception and Gazes -/- 6. Inside the gaze -/- Shaun Gallagher -/- 7. Perception and its Objects. -/- Maurita Harney -/- 8. Technological Gaze: Understanding How Technologies Transform Perception -/- Richard Lewis -/- 9. The Inhuman Gaze and Perceptual Gestalts: The Making and Unmaking of Others and Worlds -/- Anya Daly -/- Part III. Psychiatry, Psychopathology and Inhuman Gazes -/- 10. Values and Values-based Practice in Psychopathology: Combining Analytic and Phenomenological Approaches -/- G Stanghellini and K.W.M. (Bill) Fulford -/- 11. The Inhuman and Human Gaze in Psychiatry, Psychopathology and Schizophrenia. -/- Matthew Broome -/- 12. Overcoming the Gaze: Psychopathology, Affect, and Narrative. -/- Anna Bortolan -/- 13. From excess to exhaustion : The rise of burnout in a post-modern achievement society. -/- Philippe Wuyts -/- 14. Blackout Rages: The Inhibition of Episodic Memory in Extreme Berserker Episodes -/- John Protevi -/- Part IV. Beyond the Human: Divine, Posthuman and Animal Gazes -/- 15. Wondering at the Inhuman Gaze -/- Sean. D. Kelly -/- 16. What Counts as Human/ Inhuman Right Now? -/- Rosi Braidotti -/- 17. Beyond Human and Animal: Metamorphosis in Merleau-Ponty -/- Dylan Trigg -/- Part V. Sociality and Boundaries of the Human -/- 18. Voice and gaze considered together in ‘languaging’. -/- Fred Cummins -/- 19. Ethics Beyond the Human: Disability and The Inhuman -/- Jonathan Mitchell -/- 20. Social Invisibility and Emotional Blindness -/- James Jardine -/- 21. What are you looking at? Dissonance as a window on the autonomy of participatory sense-making frames. -/- Mark James. (shrink)

In 1826 Americans witnessed the spectacle of President John Quincy Adams and Vice-President John C. Calhoun taking to the press to debate the nature of power and liberty under the pseudonyms "Patrick Henry" and "Onslow". In the course of this exchange some of the most salient issues within American politics and liberty are debated, including the nature of political order, democracy, and the diffusion of political power.

Review the Istvan Kiraly V.'s book: Death and History.

A short core model induction proof of $\mathsf {AD}^{L(\mathbb {R})}$ from $\mathsf {TD} + \mathsf {DC}_{\mathbb {R}}$.

In his “Wissenschaftslogik: The Role of Logic in the Philosophy of Science,” Michael Friedman argues that Carnap’s philosophy of science “is fundamentally anti-metaphysical—he aims to use the tools of mathematical logic to dissolve rather [than] solve traditional philosophical problems—and it is precisely this point that is missed by his logically-minded contemporaries such as Hempel and Quine”. In this paper, I take issue with this claim, arguing that Quine, too, is a part of this anti-metaphysical tradition. I begin in section I (...) with Russell’s account of scientific philosophy, focusing on its critique of metaphysics and its reliance on logical constructions. I then argue that each of Carnap and Quine take up this call to scientific philosophizing but that they both find Russell’s account of logic wanting. In section II, I first provide an account of Carnap’s critique of metaphysics and its reliance on developments in logic. This is followed by a discussion of his appeal to the analytic/synthetic distinction so as to improve upon Russell’s account of logic. Section III follows this same structure but focuses on Quine. In the end, though, Quine turns not to the analytic/synthetic distinction but to holism to provide an account of logic suitable to scientific philosophy. Carnap had claimed to be “more Russellian than Russell,” and in this final move by Quine I argue that he is “being more Carnapian than Carnap.” I conclude by showing how, contrary to Friedman’s view, Quine’s rejection of the analytic/synthetic distinction does not yield a return to the kind metaphysics that he, Carnap, and Russell all objected to. (shrink)

The paper presents a new theory of perceptual demonstrative thought, the property-dependent theory. It argues that the theory is superior to both the object-dependent theory (Evans, McDowell) and the object-independent theory (Burge).

This dissertation is a collection of essays exploring the role of metaphor in Aristotle’s scientific method. Aristotle often appeals to metaphors in his scientific practice; but in the Posterior Analytics, he suggests that their use is inimical to science. Why, then, does he use them in natural science? And what does his use of metaphor in science reveal about the nature of his scientific investigations? I approach these questions by investigating the epistemic status of metaphor in Aristotelian science. In the (...) first essay, I defend an interpretation of metaphor as a type of heuristic reasoning: I claim that Aristotle uses metaphor to express conditions an explanation in natural science must meet if it is to explain regular, ordered change. These conditions specify the kinds of causes—particularly unmoved efficient causes—which the inquirer into nature is seeking. In the second essay, I look to Aristotle’s use of certain endoxa or common beliefs as explanatory principles in science, and show that his use of these principles is similar to his use of metaphor. In the final essay, I present a historical study of the analogy of art and nature, and I suggest that by looking to how the Greeks understood the role of inquiry in the arts, we can shed some light on Aristotle’s views concerning the method of inquiry he thinks the natural scientist should adopt. (shrink)

There is much to be learned philosophically from this volume, but philosophical instruction was not Kierkegaard's aim here, except in the broad sense of self-knowledge and deepened awareness. Indicating the intention of the discourses, the titles include "The Expectancy of Faith," "Love Will Hide a Multitude of Sins," "Strengthening in the Inner Being," "To Gain One's Soul in Patience," "Patience in Expectancy," and "Against Cowardliness."In tone and substance these works are in accord with the concluding words of encouragement in Either/Or, (...) which was paired with the first volume of discourses: "Ask yourself and keep on asking until you find the answer, for one may have known something many times, acknowledged it; one may have willed something many times, attempted it--and yet, only the deep inner motion, only the heart's indescribable emotion, only that will convince you that what you have acknowledged belongs to you, that no power can take it from you--for only the truth that builds up is truth for you.". (shrink)

RÉSUMÉ: Je me demande ici si les conceptions pragmatiques de la vérité peuvent être réconciliées avec les intuitions ordinaires quant à la portée de la bivalence. Je soutiens que les pragmatistes sont conduits à accepter une distinction du genre «type/occurrence» entre les formes d’une investigation et ses instanciations particulières, sous peine de banaliser leur vérificationnisme. Néanmoins, même la conception révisée que j’examine échoue à sauver les approches épistémiques de la vérité de certaines conséquences peu plausibles.